Project Thermin: Differential characterization of strains of a bacterial species, Streptococcus thermophilus, with a Nanopore Minion

Participants : Jacques Nicolas, Emeline Roux, Gregoire Siekaniec, Dominique Lavenier.

Coordinator: J. Nicolas (Inria/Irisa, GenScale, Rennes)

Duration: 36 months (Oct. 2018 – Sept. 2021)

Partners: INRA (STLO, Agrocampus Rennes, E. Guédon and Y. Le Loir).

The Thermin project aims at exploring the capacities of a low cost third generation sequencing device, the Nanopore Minion, for rapid and robust pan-genome dicrimination of bacterial strains and their phenotypes. It has started at the end of this year with the recruitment (délégation Inria) of E. Roux, a biochemist from Lorraine University and G. Siekaniec (INRA -Inria collaboration, INRA grant), a new PhD student. We will study pan-genomic representations of multiple genomes and the production of characteristic signatures of each genome in this context.